Endocrine Abstracts

BackgroundRapid induction of eu/hypothyroidism in patients with immune hyperthyroidism has been known to precipitate Thyroid eye disease (TED). Our aim was to investigate the incidence of TED in patients treated with radio-iodine therapy (RIT) at our hospital.MethodsWe examined case notes of 45 patients who underwent radio-iodine therapy for Graves’ disease with 544.7 (95% CI- 522.3 – 567.1) MBq bet...

A previously fit 36 year old lady presented with 3 days of pleuritic chest pain and SOB. A CxR showed consolidation at the left heart border. Following antibiotics she made a good recovery. On examination an incidental right thyroid nodule was identified. She was clinically euthyroid. FT4,FT3 were normal and TSH suppressed. The CxR a month later did not change. A CT scan revealed a 5x4cm mass in the left lower lobe, abutting the descending aorta and left atrium. Bronchoscopy r...

Introduction: Waist circumference serves as a key indicator of abdominal obesity and predictor of cardiovascular and metabolic risk even in children. Under the current WHO standard methodology, waist circumference is measured midway between the lowest rib and the iliac crest. However, comparison of current and earlier data is complicated as different waist circumference measurement methodologies have been used in the past. For instance, previous Czech studies commonly worked w...

Aim: To investigate total homocysteine (Hcy), cysteine (Cys), glutathione (GSH), lipid and steroid sulfate levels in women with polycystic ovary syndrome (PCOS).Methods: The blood levels of Hcy, Cys, GSH (determined by HPLC), total and HDL-cholesterol, insulin (IRMA),DHEA and DHEAS, cortisol, pregnenolone, 17-hydroxy-pregnenolone and pregnenolone-sulphate (all RIA) were examined in 44 women with PCOS (age 24+/-7yrs) and 12 healthy controls (34+/-5yrs) in...

A 64-year-old lady presented with weight gain, tiredness, palpitations and tremor. She had no goitre and no other extra thyroidal manifestations. Both TSH and thyroid peroxidase antibodies (>1300) were elevated and she was treated by her GP with Thyroxine 50 mcg daily. She felt a lot worse on this, so it was discontinued and a full thyroid hormone profile was checked (see Table 1) which prompted referral; to Endocrinology.Other pituitary hormone leve...

A 44-year-old man referred with erectile dysfunction was found to have hypogonadotrophic hypogonadism (HH), but otherwise apparently normal anterior pituitary function (LH 1.6 & FSH 2.7 IU/l; T 3.4 & cortisol 516 nmol/l; PRL 103, GH 5.5 & TSH 2.8 mU/l; f-T4 13, f-T3 4.8 & f-T 128 pmol/l; ferritin 103 ug/l). He appeared normally virilised, with central obesity (BMI 36 kg.m−2, collar size 46 cm) and symptomatic sleep apnoea (SA). MRI showed a rig...

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Adipokines and pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between adiponectin, resistin, leptin, interleukin (IL) 4, IL6, IL10, tumor necrosis factor α (T...

Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEA-S) are major adrenal secretory products in humans, but their biological function is not still fully explained. Some studies reported negative correlation of DHEA(S) with BMI, fat distribution, and correlations with insulin sensitivity or lipid spectra, but the results are often controversial. Our objective was to assess the correlations of DHEA and DHEA-S levels in Czech non-diabetic population with anthropometric,...